Blue Eye™ Submucosal Tissue Polyp Lifting Agent

Submucosal tissue lifting is a technique used during endoscopic procedures to create a space between the mucosal and submucosal layers of the gastrointestinal tract. This separation facilitates safer and more precise resection of lesions or polyps, improving procedural outcomes.

A submucosal tissue lifting agent is a substance utilised to separate the mucosal and submucosal layers during endoscopic procedures. This agent creates a cushioning effect, enhancing visualisation and manipulation of target tissue. Blue Eye™ is a leading submucosal tissue lifting agent, trusted globally.

Blue Eye™ submucosal tissue lifting agent typically comprises biocompatible materials such as hyaluronic acid. This sterile composition ensures safety within the gastrointestinal tract while providing effective lifting and stability during procedures.

The duration of the submucosal tissue lift varies, influenced by factors like the agent used and patient-specific characteristics. Generally, the lifting effect is temporary, lasting throughout the procedure. Blue Eye™ offers over 45 minutes of rigidity, reducing procedure time and enhancing success rates.

Using a submucosal tissue lifting agent involves injecting the solution into the submucosal layer beneath the target tissue. Blue Eye™ is conveniently packaged in a pre-filled syringe for easy use. To use, unfasten the cap, attach the syringe to the Luer-lock fitting. Detailed instructions are available in our electronic Instructions for Use (eIFUs).

Submucosal tissue lifting agents play a pivotal role in endoscopic procedures by improving visualisation, providing better access to target tissue, and enabling safer and more effective resection of lesions or polyps. Their use enhances procedural outcomes and patient care, making them indispensable tools in endoscopy. This composition ensures safety within the gastrointestinal tract while providing effective lifting and stability during procedures.

Choosing Blue Eye™ over saline for submucosal tissue lifting in endoscopy offers significant advantages. Blue Eye™ provides a sterile solution that is ready to use without the need for premixing or shaking, saving valuable time during procedures and ensuring convenience for endoscopists. With Blue Eye™, there's no preparation required, allowing endoscopists to immediately utilise the solution and streamline the workflow. The consistent quality and performance of Blue Eye™ enhances procedural predictability allowing endoscopists to focus on patient care. Overall, Blue Eye™ offers a convenient, efficient, and reliable solution for submucosal tissue lifting, making it a preferred choice over saline.

Very easy! Switching to Blue Eye™ is straightforward. It comes in a 5ml sterile, pre-filled syringe with a standard Luer lock connection. If you're currently using another lifting agent, you'll find the transition to Blue Eye™ smooth, reliable and fully supported by our team. We’re also happy to provide free-of-charge samples so you can carry out your own clinical evaluation and feel confident in making the switch.

At present, Blue Eye™ is available in a 5ml size. However, we are actively working with our manufacturers to introduce a 10ml version. We know that they are currently working on this and are preparing to submit it to the MDR authorities. We look forward to providing you with the 10ml option as soon as it's available.

According to the paper in the reference below, it has been proved by clinical trials that the mixture of hyaluronic acid and epinephrine helps control bleeding without side effects.

• If the doctor needs to lower the risk of bleeding, it is suggested to inject haemostatic factor prior to the injection of Blue Eye™.
• If it is necessary to mix Blue Eye™ and the haemostatic factor during the procedure, 50 ml of Blue Eye™ needs to be transferred to a conical tube and then mix the haemostatic factor (such as adrenaline) as much as 0.001% w/v of the solution.

Reference: [1] Yamamoto, Hironori, et al. "Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate." Gastrointestinal Endoscopy 56.4 (2002): 507-512